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ALBENDAZOLE

ALBENDAZOLE

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Albendazole is an Antihelminthic.

Albendazole is a broad-spectrum, synthetic benzimidazole-derivative anthelmintic. Albendazole interferes with the reproduction and survival of helminths by inhibiting the formation of microtubules from tubulin. This leads to an impaired uptake of glucose, a depletion of glycogen stores, and results in the worm's death. Albendazole is used in the treatment of dog and pork tapeworm-causing diseases, including hydatid disease and neurocysticercosis. Albendazole may also be used to treat a variety of other roundworm infections.

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Chemical Description :- 

 Description :- White to slightly yellowish powder.

 Solubility  :- Freely soluble in anhydrous formic acid; very sllghtly soluble in                   methvlcne chloride ; practically.

Identification :- 1) By IR IR spectrum of test sample should he concordant with IR                       Complies.spectrum ot simmlar preparation ot’Albendazolc                             of working standard.

                                     2)   Appearence of solution :-The solution should clear .

                   5. Related substances by Liquid chromatography

                      I) Impurity A J Not more than 0.75 %.- not detected

                     ii) Impurity B Not more than 0.75 %- 0.07%

                      i) Impurity C Not more than 0.75 %- not detected

                     iv) Impurity D Not more than 0.75 % - 0.19 %

                      V) Impurity E Not more than 0.75 % - not detected

                      yi) impurity F Not more than 0.75%- 0.11%

                     Vii) Unspecified Not more than 0.1 %.impirity

                  6. Loss on drying :- Not more than 0.5% - 0.17 %

                                    7. Sulphated ash :-  Not more than 0.2% - 0.10%

                                    8. Assay on dried basis - Not less than 98.00% and not more than                        by titration           102 %